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Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-κB.

Abstract:

An intriguing biological question relating to cell signaling is how the inflammatory mediator NF-kB and the tumour suppressor protein p53 can be induced by similar triggers, like DNA damage or infection, yet have seemingly opposing or sometimes cooperative biological functions. For example, the NF-κB subunit RelA/p65 has been shown to inhibit apoptosis, whereas p53 induces apoptosis. One potential explanation may be their co-regulation by common cellular factors: inhibitor of Apoptosis Stimul...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.18632/oncotarget.6478

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Oxford Ludwig Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Oxford Ludwig Institute
Role:
Author
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Ludwig Institute for Cancer Research More from this funder
Publisher:
Impact Journals Publisher's website
Journal:
Oncotarget Journal website
Volume:
6
Issue:
40
Pages:
42478-42490
Publication date:
2015-12-01
DOI:
EISSN:
1949-2553
Source identifiers:
584150
Language:
English
Keywords:
Pubs id:
pubs:584150
UUID:
uuid:81f7754a-47f5-4d3d-87a0-e118bd963b4b
Local pid:
pubs:584150
Deposit date:
2016-01-15

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