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Journal article

Personalised medicine, disruptive innovation and ‘trailblazer’ guidelines: Case study and theorization of an unsuccessful change effort

Abstract:

Policy Points:
- For complex reasons, the promise of “precision medicine” based on molecular pathways remains unrealized for many conditions.
- Clinical practice guidelines (theoretically, at least) can act as “trailblazers” to introduce tests and treatments that reflect precision medicine discoveries.
- We describe a detailed case study from the United Kingdom in which such an attempt was (so far) unsuccessful and show how this case provides generalizabl...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
Primary Care Health Sciences
ORCID:
0000-0003-3352-943X
Greenhalgh, T More by this author
Publisher:
Wiley Publisher's website
Journal:
Milbank Quarterly Journal website
Volume:
98
Issue:
2
Pages:
581-617
Publication date:
2020-05-20
Acceptance date:
2019-11-22
DOI:
EISSN:
1468-0009
ISSN:
0887-378X
Pubs id:
pubs:1080846
UUID:
uuid:81e962f4-cc37-4ebb-94e1-618ed5acf4ae
Source identifiers:
1080846
Local pid:
pubs:1080846

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