Journal article icon

Journal article

Low-frequency variation in TP53 has large effects on head circumference and intracranial volume

Abstract:

Cranial growth and development is a complex process which affects the closely related traits of head circumference (HC) and intracranial volume (ICV). The underlying genetic influences shaping these traits during the transition from childhood to adulthood are little understood, but might include both age-specific genetic factors and low-frequency genetic variation. Here, we model the developmental genetic architecture of HC, showing this is genetically stable and correlated with genetic deter...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

Actions


Access Document


Files:
Publisher copy:
10.1038/s41467-018-07863-x

Authors


More by this author
ORCID:
0000-0001-7793-7326
More by this author
ORCID:
0000-0002-5797-1241
More by this author
ORCID:
0000-0002-9405-9550
More by this author
ORCID:
0000-0002-9801-5774
Expand authors...
Publisher:
Nature Research Publisher's website
Journal:
Nature Communications Journal website
Volume:
10
Pages:
Article: 357
Publication date:
2019-01-21
Acceptance date:
2018-11-12
DOI:
EISSN:
2041-1723
Pubs id:
pubs:966705
URN:
uri:81e58373-b2e7-4cc8-b3cf-be159d759f08
UUID:
uuid:81e58373-b2e7-4cc8-b3cf-be159d759f08
Local pid:
pubs:966705
Language:
English

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP