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p21-activated kinase 1: PAK'ed with potential.

Abstract:

The p21-activated kinases (PAKs) are central players in growth factor signaling networks and morphogenetic processes that control proliferation, cell polarity, invasion and actin cytoskeleton organization. This raises the possibility that interfering with PAK activity may produce significant anti-tumor activity. In this perspective, we summarize recent data concerning the contribution of the PAK family member, PAK1, in growth factor signaling and tumorigenesis. We further discuss mechanisms b...

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Publication status:
Published

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Authors


Haverty, PM More by this author
Harris, AL More by this author
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Journal:
Oncotarget
Volume:
2
Issue:
6
Pages:
491-496
Publication date:
2011-06-05
EISSN:
1949-2553
ISSN:
1949-2553
URN:
uuid:81db76ce-1231-4afa-ad19-3c2f02f5bcb8
Source identifiers:
316115
Local pid:
pubs:316115

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