Journal article
Altered polarity and expression of H+-ATPase without ultrastructural changes in kidneys of Dent's disease patients.
- Abstract:
-
BACKGROUND: Dent's disease is a proximal tubule (PT) disorder characterized by low-molecular-weight proteinuria (LWMP) that may be associated with hypercalciuria, nephrocalcinosis, and renal failure. It is caused by inactivating mutations of the renal chloride channel ClC-5, which colocalizes with the vacuolar H+-ATPase in PT cells and alpha-type intercalated cells. Examinations of knockout mice have established the role of ClC-5 in PT endocytosis, but the consequences of ClC-5 mutations on ...
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- Publication status:
- Published
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- Publisher copy:
- 10.1046/j.1523-1755.2003.00851.x
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Bibliographic Details
- Journal:
- Kidney international
- Volume:
- 63
- Issue:
- 4
- Pages:
- 1285-1295
- Publication date:
- 2003-04-01
- DOI:
- EISSN:
-
1523-1755
- ISSN:
-
0085-2538
- Source identifiers:
-
16430
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:16430
- UUID:
-
uuid:81d38e95-73c1-4617-b747-06b53b6a1f0a
- Local pid:
- pubs:16430
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2003
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