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Altered polarity and expression of H+-ATPase without ultrastructural changes in kidneys of Dent's disease patients.

Abstract:

BACKGROUND: Dent's disease is a proximal tubule (PT) disorder characterized by low-molecular-weight proteinuria (LWMP) that may be associated with hypercalciuria, nephrocalcinosis, and renal failure. It is caused by inactivating mutations of the renal chloride channel ClC-5, which colocalizes with the vacuolar H+-ATPase in PT cells and alpha-type intercalated cells. Examinations of knockout mice have established the role of ClC-5 in PT endocytosis, but the consequences of ClC-5 mutations on ...

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Publication status:
Published

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Journal:
Kidney international
Volume:
63
Issue:
4
Pages:
1285-1295
Publication date:
2003-04-05
DOI:
EISSN:
1523-1755
ISSN:
0085-2538
URN:
uuid:81d38e95-73c1-4617-b747-06b53b6a1f0a
Source identifiers:
16430
Local pid:
pubs:16430

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