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Small molecule targeting malaria merozoite surface protein-1 (MSP-1) prevents host invasion of divergent plasmodial species.

Abstract:

Malaria causes nearly 1 million deaths annually. Recent emergence of multidrug resistance highlights the need to develop novel therapeutic interventions against human malaria. Given the involvement of sugar binding plasmodial proteins in host invasion, we set out to identify such proteins as targets of small glycans. Combining multidisciplinary approaches, we report the discovery of a small molecule inhibitor, NIC, capable of inhibiting host invasion through interacting with a major invasion-...

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Publication status:
Published

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Publisher copy:
10.1093/infdis/jiu296

Authors


Chandramohanadas, R More by this author
Russell, B More by this author
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Publisher:
Oxford University Press
Journal:
The Journal of infectious diseases
Volume:
210
Issue:
10
Pages:
1616-1626
Publication date:
2014-11-05
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
URN:
uuid:81cc5a80-c5c5-4a48-a06d-0a87ad72a053
Source identifiers:
466079
Local pid:
pubs:466079

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