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Strategic role of the ubiquitin-dependent segregase p97 (VCP or Cdc48) in DNA replication.

Abstract:

Genome amplification (DNA synthesis) is one of the most demanding cellular processes in all proliferative cells. The DNA replication machinery (also known as the replisome) orchestrates genome amplification during S-phase of the cell cycle. Genetic material is particularly vulnerable to various events that can challenge the replisome during its assembly, activation (firing), progression (elongation) and disassembly from chromatin (termination). Any disturbance of the replisome leads to stalli...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1007/s00412-016-0587-4

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology, CRUK/MRC Ox Inst for Radiation Oncology
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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
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Funding agency for:
Halder, S
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Publisher:
Springer Berlin Heidelberg Publisher's website
Journal:
Chromosoma Journal website
Pages:
1-16
Publication date:
2016
DOI:
EISSN:
1432-0886
ISSN:
0009-5915
URN:
uuid:81bee60d-ce2b-43b9-aba7-2bee218da8cb
Source identifiers:
616866
Local pid:
pubs:616866

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