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Blocking of carbon nanotube based nanoinjectors by lipids: a simulation study.

Abstract:

Carbon nanotubes (CNTs) are possible nanoinjectors for the introduction of therapeutic agents into cells. To explore their interactions with a lipid bilayer membrane and to model the nanoinjection process, we used coarse-grained molecular dynamics to simulate the penetration of dipalmitoylphosphatidylcholine (DPPC) bilayers by single-walled CNTs. Lipids are extracted from a bilayer during CNT penetration and reside on both the inner and the outer tube surfaces. Lipids that interact with the C...

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Publication status:
Published

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Publisher copy:
10.1021/nl801217f

Authors


Wallace, EJ More by this author
Sansom, MS More by this author
Journal:
Nano letters
Volume:
8
Issue:
9
Pages:
2751-2756
Publication date:
2008-09-05
DOI:
EISSN:
1530-6992
ISSN:
1530-6984
URN:
uuid:81bc9946-bf26-4345-936d-93e25089fa6d
Source identifiers:
100909
Local pid:
pubs:100909

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