- Abstract:
-
Potassium channels selectively conduct K+ ions across cell membranes and have key roles in cell excitability. Their opening and closing can be spontaneous or controlled by membrane voltage or ligand binding. We used Ba2+ as a probe to determine the location of the ligand-sensitive gate in an inwardly rectifying K+ channel (Kir6.2). To a K+ channel, Ba2+ and K+ are of similar sizes, but Ba2+ blocks the pore by binding within the selectivity filter. We found that internal Ba2+ could still acces...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1038/embor708
-
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- Journal:
- EMBO REPORTS
- Volume:
- 4
- Issue:
- 1
- Pages:
- 70-75
- Publication date:
- 2003-01-05
- DOI:
- ISSN:
-
1469-221X
- URN:
-
uuid:81bb0f96-c683-4072-9d60-644b4546331f
- Source identifiers:
-
114584
- Local pid:
- pubs:114584
- Language:
- English
- Copyright date:
- 2003
Journal article
The ligand-sensitive gate of a potassium channel lies close to the selectivity filter
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