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The ligand-sensitive gate of a potassium channel lies close to the selectivity filter

Abstract:

Potassium channels selectively conduct K+ ions across cell membranes and have key roles in cell excitability. Their opening and closing can be spontaneous or controlled by membrane voltage or ligand binding. We used Ba2+ as a probe to determine the location of the ligand-sensitive gate in an inwardly rectifying K+ channel (Kir6.2). To a K+ channel, Ba2+ and K+ are of similar sizes, but Ba2+ blocks the pore by binding within the selectivity filter. We found that internal Ba2+ could still acces...

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Publication status:
Published

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Publisher copy:
10.1038/embor708

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
Journal:
EMBO REPORTS
Volume:
4
Issue:
1
Pages:
70-75
Publication date:
2003-01-05
DOI:
ISSN:
1469-221X
URN:
uuid:81bb0f96-c683-4072-9d60-644b4546331f
Source identifiers:
114584
Local pid:
pubs:114584
Language:
English

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