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Enantiomeric 2-acetamido-1,4-dideoxy-1,4-iminoribitols as potential pyrrolidine hexosaminidase inhibitors

Abstract:
2-Acetamido-1,4-imino-1,2,4-trideoxy-D-ribitol (DRBNAc) and the enantiomeric LRBNAc were prepared as potential hexosaminidase inhibitors from L- and D-lyxonolactone, respectively. Neither N-benzyl-DRBNAc nor N-benzyl-LRBNAc showed any inhibition of α- or β-hexosaminidases or any other glycosidase. © 2010 Académie des sciences. Published by Elsevier Masson SAS. All rights reserved.
Publication status:
Published

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Publisher copy:
10.1016/j.crci.2010.03.020

Authors


Rountree, JSS More by this author
Butters, TD More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Journal:
COMPTES RENDUS CHIMIE
Volume:
14
Issue:
1
Pages:
126-133
Publication date:
2011-01-05
DOI:
ISSN:
1631-0748
URN:
uuid:81b12c82-a8e4-4078-99ff-bef7e4a1a343
Source identifiers:
138948
Local pid:
pubs:138948

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