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Integrated computational prediction and experimental validation identifies promiscuous T cell epitopes in the proteome of Mycobacterium bovis

Abstract:

The discovery of novel antigens is an essential requirement in devising new diagnostics or vaccines for use in control programmes against human tuberculosis (TB) and bovine tuberculosis (bTB). Identification of potential epitopes recognised by CD4+ T cells requires prediction of peptide binding to MHC class-II, an obligatory prerequisite for T cell recognition. To comprehensively prioritise potential MHC-II-binding epitopes from Mycobacterium bovis, the agent of bTB and zoonotic TB in humans,...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1099/mgen.0.000071

Authors


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ORCID:
0000-0003-3020-7945
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ORCID:
0000-0002-3974-0810
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Subgroup:
KIR
ORCID:
0000-0003-3899-3872
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Grant:
ERA_NET 11/RD/EMIDA/1 (as part of the EMIDA project MYCOBACTDIAGNOSIS)
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Grant:
SE3270 (as part of the EMIDA project MYCOBACTDIAGNOSIS)
Publisher:
Microbiology Society Publisher's website
Journal:
Microbial Genomics Journal website
Volume:
2
Issue:
8
Pages:
Article: e000071
Publication date:
2016-08-25
Acceptance date:
2016-05-26
DOI:
ISSN:
2057-5858
Pubs id:
pubs:809629
URN:
uri:81a4e374-5b51-4f25-9774-8ea86e3ba1a1
UUID:
uuid:81a4e374-5b51-4f25-9774-8ea86e3ba1a1
Local pid:
pubs:809629
Language:
English
Keywords:

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