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Functional characterisation of cis-regulatory elements governing dynamic Eomes expression in the early mouse embryo

Abstract:

The T-box transcription factor (TF) Eomes is a key regulator of cell fate decisions during early mouse development. The cis-acting regulatory elements that direct expression in the anterior visceral endoderm (AVE), primitive streak (PS) and definitive endoderm (DE) have yet to be defined. Here, we identified three gene-proximal enhancer-like sequences (PSE_a, PSE_b and VPE) that faithfully activate tissue specific expression in transgenic embryos. However, targeted deletion experiments demons...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1242/dev.147322

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Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
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Department:
Oxford, MSD, RDM, Weatherall Insti. of Molecular Medicine
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Author
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Department:
Oxford, MSD, RDM, Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Department:
Oxford, MSD, RDM, Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Department:
Oxford, MSD, RDM, Weatherall Insti. of Molecular Medicine
Role:
Author
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Funding agency for:
Higgs, DR
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Funding agency for:
Hughes, JR
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Publisher:
Company of Biologists Publisher's website
Journal:
Development Journal website
Volume:
144
Issue:
7
Pages:
1249-1260
Publication date:
2017-02-07
Acceptance date:
2017-01-25
DOI:
EISSN:
1477-9129
ISSN:
0950-1991
Pubs id:
pubs:679683
URN:
uri:81a3795b-461d-4525-9376-8e9890b7b161
UUID:
uuid:81a3795b-461d-4525-9376-8e9890b7b161
Local pid:
pubs:679683

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