Journal article
Functional characterisation of cis-regulatory elements governing dynamic Eomes expression in the early mouse embryo
- Abstract:
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The T-box transcription factor (TF) Eomes is a key regulator of cell fate decisions during early mouse development. The cis-acting regulatory elements that direct expression in the anterior visceral endoderm (AVE), primitive streak (PS) and definitive endoderm (DE) have yet to be defined. Here, we identified three gene-proximal enhancer-like sequences (PSE_a, PSE_b and VPE) that faithfully activate tissue specific expression in transgenic embryos. However, targeted deletion experiments demons...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, pdf, 9.3MB, Terms of use)
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- Publisher copy:
- 10.1242/dev.147322
Authors
Funding
+ Medical Research Council
More from this funder
Funding agency for:
Higgs, D
Hughes, J
Grant:
4050189188
4050189188
+ Wellcome Trust
More from this funder
Funding agency for:
Higgs, D
Hughes, J
Robertson, E
Grant:
4050189188
4050189188
WT 102811
Bibliographic Details
- Publisher:
- Company of Biologists
- Journal:
- Development More from this journal
- Volume:
- 144
- Issue:
- 7
- Pages:
- 1249-1260
- Publication date:
- 2017-02-07
- Acceptance date:
- 2017-01-25
- DOI:
- EISSN:
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1477-9129
- ISSN:
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0950-1991
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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pubs:679683
- UUID:
-
uuid:81a3795b-461d-4525-9376-8e9890b7b161
- Local pid:
-
pubs:679683
- Deposit date:
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2017-03-08
Terms of use
- Copyright holder:
- © 2017 Published by The Company of Biologists Ltd
- Copyright date:
- 2017
- Notes:
-
© 2017. Published by The Company of Biologists Ltd http://creativecommons.org/licenses/by/3.0
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
- Licence:
- CC Attribution (CC BY)
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