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Young-onset amyotrophic lateral sclerosis: Historical and other observations

Abstract:

There is a wide range of age at initial symptom onset in amyotrophic lateral sclerosis despite a mean age of 65 years in population-based studies. 'Young-onset' amyotrophic lateral sclerosis typically refers to patients younger than ∼45 years and accounts for about 10 of cases in contemporary series. A review of published cases of amyotrophic lateral sclerosis from 1850 to 1950 revealed a far higher proportion of cases with young onset (>50), with a steady decline to the contemporary figur...

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Publisher copy:
10.1093/brain/aws144

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Barnwell, J More by this author
Al-Chalabi, A More by this author
Journal:
Brain
Volume:
135
Issue:
9
Pages:
2883-2891
Publication date:
2012-09-05
DOI:
EISSN:
1460-2156
ISSN:
0006-8950
URN:
uuid:8190f0f4-7163-4fe5-bb39-efe431145de5
Source identifiers:
352938
Local pid:
pubs:352938

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