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Group epitope mapping considering relaxation of the ligand (GEM-CRL): including longitudinal relaxation rates in the analysis of saturation transfer difference (STD) experiments.

Abstract:

In the application of saturation transfer difference (STD) experiments to the study of protein-ligand interactions, the relaxation of the ligand is one of the major influences on the experimentally observed STD factors, making interpretation of these difficult when attempting to define a group epitope map (GEM). In this paper, we describe a simplification of the relaxation matrix that may be applied under specified experimental conditions, which results in a simplified equation reflecting the...

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Publication status:
Published

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Publisher copy:
10.1016/j.jmr.2009.11.015

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
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Institution:
University of Oxford
Department:
Oxford, MPLS, Physics, Atomic and Laser Physics
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Journal:
Journal of magnetic resonance (San Diego, Calif. : 1997)
Volume:
203
Issue:
1
Pages:
1-10
Publication date:
2010-03-05
DOI:
EISSN:
1096-0856
ISSN:
1090-7807
URN:
uuid:817e73ae-9ebb-4da1-a431-22835af0d0be
Source identifiers:
21803
Local pid:
pubs:21803

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