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Group epitope mapping considering relaxation of the ligand (GEM-CRL): including longitudinal relaxation rates in the analysis of saturation transfer difference (STD) experiments.

Abstract:

In the application of saturation transfer difference (STD) experiments to the study of protein-ligand interactions, the relaxation of the ligand is one of the major influences on the experimentally observed STD factors, making interpretation of these difficult when attempting to define a group epitope map (GEM). In this paper, we describe a simplification of the relaxation matrix that may be applied under specified experimental conditions, which results in a simplified equation reflecting the...

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Publication status:
Published

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Publisher copy:
10.1016/j.jmr.2009.11.015

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Physics
Sub department:
Atomic & Laser Physics
Role:
Author
Journal:
Journal of magnetic resonance (San Diego, Calif. : 1997)
Volume:
203
Issue:
1
Pages:
1-10
Publication date:
2010-03-01
DOI:
EISSN:
1096-0856
ISSN:
1090-7807
Source identifiers:
21803
Language:
English
Keywords:
Pubs id:
pubs:21803
UUID:
uuid:817e73ae-9ebb-4da1-a431-22835af0d0be
Local pid:
pubs:21803
Deposit date:
2012-12-19

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