Journal article
Host candidate gene polymorphisms and clearance of drug-resistant Plasmodium falciparum parasites.
- Abstract:
- Resistance to anti-malarial drugs is a widespread problem for control programmes for this devastating disease. Molecular tests are available for many anti-malarial drugs and are useful tools for the surveillance of drug resistance. However, the correlation of treatment outcome and molecular tests with particular parasite markers is not perfect, due in part to individuals who are able to clear genotypically drug-resistant parasites. This study aimed to identify molecular markers in the human genome that correlate with the clearance of malaria parasites after drug treatment, despite the drug resistance profile of the protozoan as predicted by molecular approaches.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, pdf, 550.1KB, Terms of use)
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- Publisher copy:
- 10.1186/1475-2875-10-250
Authors
- Publisher:
- BioMed Central
- Journal:
- Malaria Journal More from this journal
- Volume:
- 10
- Issue:
- 1
- Article number:
- 250
- Publication date:
- 2011-01-01
- DOI:
- EISSN:
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1475-2875
- ISSN:
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1475-2875
- Language:
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English
- Keywords:
- UUID:
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uuid:8170b0c9-90af-41c0-89a2-b47aa6c79276
- Local pid:
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pubs:186139
- Source identifiers:
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186139
- Deposit date:
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2012-12-19
Terms of use
- Copyright holder:
- Diakite et al
- Copyright date:
- 2011
- Notes:
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file: :C$$:/Users/dominic/Dropbox/Refs/2011/Diakite et al._2011_Host candidate gene polymorphisms and clearance of drug-resistant Plasmodium falciparum parasites.pdf:pdf
keywords: Adolescent,Africa,Antimalarials,Antimalarials: administration and dosage,Antimalarials: pharmacology,Child,Child, Preschool,Drug Resistance,Female,Genomics,Genomics: methods,Humans,Malaria, Falciparum,Malaria, Falciparum: genetics,Malaria, Falciparum: immunology,Male,Mass Spectrometry,Mass Spectrometry: methods,Plasmodium falciparum,Plasmodium falciparum: drug effects,Plasmodium falciparum: immunology,Plasmodium falciparum: isolation and purification,Polymorphism, Single Nucleotide
pmid: 21867552 © 2011 Diakite et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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