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An investigation to dissociate the analgesic and anesthetic properties of ketamine using functional magnetic resonance imaging.

Abstract:

BACKGROUND: Anatomic sites within the brain, which activate in response to noxious stimuli, can be identified with the use of functional magnetic resonance imaging. The aim of this study was to determine whether the analgesic effects of ketamine could be imaged. METHODS: Ketamine was administered to eight healthy volunteers with use of a target-controlled infusion to three predicted plasma concentrations: 0 (saline), 50 (subanalgesic), and 200 ng/ml (analgesic, subanesthetic). Volunteers rec...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Role:
Author
Journal:
Anesthesiology
Volume:
100
Issue:
2
Pages:
292-301
Publication date:
2004-02-05
DOI:
EISSN:
1528-1175
ISSN:
0003-3022
URN:
uuid:8169766b-925b-4470-a100-a59090421e79
Source identifiers:
241947
Local pid:
pubs:241947

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