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Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

Abstract:

By combining genome-wide association data from 8,130 individuals with type 2 diabetes (T2D) and 38,987 controls of European descent and following up previously unidentified meta-analysis signals in a further 34,412 cases and 59,925 controls, we identified 12 new T2D association signals with combined P 5 × 10 8. These include a second independent signal at the KCNQ1 locus; the first report, to our knowledge, of an X-chromosomal association (near DUSP9); and a further instance of overlap betwee...

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Publication status:
Published

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Publisher copy:
10.1038/ng.609

Authors


Voight, BF More by this author
Steinthorsdottir, V More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
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Journal:
NATURE GENETICS
Volume:
42
Issue:
7
Pages:
579-U155
Publication date:
2010-07-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:81510c32-c108-482e-988d-51b5b19f70b4
Source identifiers:
63749
Local pid:
pubs:63749
Language:
English

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