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Low multiplication rates of African Plasmodium falciparum isolates and lack of association of multiplication rate and red blood cell selectivity with malaria virulence.

Abstract:

Two potential malaria virulence factors, parasite multiplication rate (PMR) and red blood cell selectivity (measured as selectivity index [SI]), were assessed in Plasmodium falciparum clinical isolates from Mali and Kenya. At both sites, PMRs were low (Kenya median = 2.2, n = 33; Mali median = 2.6, n = 61) and did not differ significantly between uncomplicated and severe malaria cases. Malian isolates from hyperparasitemic patients had significantly lower PMRs (median = 1.8, n = 19) than othe...

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Publication status:
Published

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Journal:
The American journal of tropical medicine and hygiene
Volume:
74
Issue:
4
Pages:
554-563
Publication date:
2006-04-05
EISSN:
1476-1645
ISSN:
0002-9637
URN:
uuid:81256613-e393-40a1-89cd-3408d71083ea
Source identifiers:
90507
Local pid:
pubs:90507

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