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Journal article

Degenerate evolution of the hedgehog gene in a hemichordate lineage.

Abstract:

The discovery of a set of highly conserved genes implicated in patterning during animal development represents one of the most striking findings from the field of evolutionary developmental biology. Existence of these "developmental toolkit" genes in diverse taxa, however, does not necessarily imply that they always perform the same functions. Here, we demonstrate functional evolution in a major toolkit gene. hedgehog (hh) encodes a protein that undergoes autocatalytic cleavage, releasing a s...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.0810430106

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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
106
Issue:
18
Pages:
7491-7494
Publication date:
2009-05-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:811deae6-c4a4-4af3-a5e9-93ef016282af
Source identifiers:
204479
Local pid:
pubs:204479

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