Journal article
Glucocorticoids promote Von Hippel Lindau degradation and Hif-1α stabilization
- Abstract:
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Glucocorticoid (GC) and hypoxic transcriptional responses play a central role in tissue homeostasis and regulate the cellular response to stress and inflammation, highlighting the potential for cross-talk between these two signaling pathways. We present results from an unbiased in vivo chemical screen in zebrafish that identifies GCs as activators of hypoxia-inducible factors (HIFs) in the liver. GCs activated consensus hypoxia response element (HRE) reporters in a glucocorticoid receptor (GR...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
-
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(Accepted manuscript, pdf, 5.0MB)
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- Publisher copy:
- 10.1073/pnas.1705338114
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Authors
Funding
+ National Institute for Health Research
More from this funder
Grant:
Birmingham Liver Biomedical
Research Unit
Bibliographic Details
- Publisher:
- National Academy of Sciences Publisher's website
- Journal:
- Proceedings of the National Academy of Sciences Journal website
- Volume:
- 114
- Issue:
- 37
- Pages:
- 9948–9953
- Publication date:
- 2017-08-29
- Acceptance date:
- 2017-07-25
- DOI:
- EISSN:
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1091-6490
- ISSN:
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0027-8424
- Pmid:
-
28851829
- Source identifiers:
-
727866
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:727866
- UUID:
-
uuid:8108f28f-c154-4754-ae7f-a3d303a6864f
- Local pid:
- pubs:727866
- Deposit date:
- 2017-09-23
Terms of use
- Copyright holder:
- Vettori et al
- Copyright date:
- 2017
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from National Academy of Sciences at: https://doi.org/10.1073/pnas.1705338114
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