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Glucocorticoids promote Von Hippel Lindau degradation and Hif-1α stabilization

Abstract:

Glucocorticoid (GC) and hypoxic transcriptional responses play a central role in tissue homeostasis and regulate the cellular response to stress and inflammation, highlighting the potential for cross-talk between these two signaling pathways. We present results from an unbiased in vivo chemical screen in zebrafish that identifies GCs as activators of hypoxia-inducible factors (HIFs) in the liver. GCs activated consensus hypoxia response element (HRE) reporters in a glucocorticoid receptor (GR...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1073/pnas.1705338114

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Grant:
Birmingham Liver Biomedical Research Unit
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Grant:
FP7 PathCo HEALTH 597F3- 2012–305578
Publisher:
National Academy of Sciences Publisher's website
Journal:
Proceedings of the National Academy of Sciences Journal website
Volume:
114
Issue:
37
Pages:
9948–9953
Publication date:
2017-08-29
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Pubs id:
pubs:727866
URN:
uri:8108f28f-c154-4754-ae7f-a3d303a6864f
UUID:
uuid:8108f28f-c154-4754-ae7f-a3d303a6864f
Local pid:
pubs:727866
Paper number:
37

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