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Function, gene organization and protein structures of 11beta-hydroxysteroid dehydrogenase isoforms.

Abstract:

Enzymatic interconversion of active and inactive glucocorticoid hormone is important, and is carried out physiologically by 11beta-hydroxysteroid dehydrogenase (11beta-HSD) isoforms, explaining their role in cellular and toxicological processes. Two forms of the enzyme, 11beta-HSD-1 and 11beta-HSD-2, belonging to the protein superfamily of short-chain dehydrogenases/reductases, have been structurally and functionally characterised. Although displaying dehydrogenase and reductase activities in...

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Authors


Oppermann, UC More by this author
Persson, B More by this author
Jörnvall, H More by this author
Journal:
European journal of biochemistry / FEBS
Volume:
249
Issue:
2
Pages:
355-360
Publication date:
1997-10-05
DOI:
EISSN:
1432-1033
ISSN:
0014-2956
URN:
uuid:80ff6633-6b29-4877-bd8a-88a322dbc554
Source identifiers:
108305
Local pid:
pubs:108305

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