Function, gene organization and protein structures of 11beta-hydroxysteroid dehydrogenase isoforms.

Journal article

Enzymatic interconversion of active and inactive glucocorticoid hormone is important, and is carried out physiologically by 11beta-hydroxysteroid dehydrogenase (11beta-HSD) isoforms, explaining their role in cellular and toxicological processes. Two forms of the enzyme, 11beta-HSD-1 and 11beta-HSD-2, belonging to the protein superfamily of short-chain dehydrogenases/reductases, have been structurally and functionally characterised. Although displaying dehydrogenase and reductase activities in...

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Authors: Oppermann, U; Persson, B; Jörnvall, H

• Journal: European journal of biochemistry / FEBS
• Volume: 249
• Issue: 2
• Pages: 355-360
• Publication date: 1997-10-01
• DOI: 10.1111/j.1432-1033.1997.t01-1-00355.x
• EISSN: 1432-1033
• ISSN: 0014-2956
• Language: English
• Keywords: Amino Acid Sequence; Sequence Alignment; Hydroxysteroid Dehydrogenases; Substrate Specificity; Molecular Sequence Data; Protein Conformation; Models, Structural; Animals; 11-beta-Hydroxysteroid Dehydrogenases; Isoenzymes; Humans; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Mammals