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Journal article

Cellular reprogramming: a new approach to modelling Parkinson's disease.

Abstract:

iPSCs (induced pluripotent stem cells) offer an unparalleled opportunity to generate and study physiologically relevant cell types in culture. iPSCs can be generated by reprogramming almost any somatic cell type using pluripotency factors such as Oct4, SOX2, Nanog and Klf4. By reprogramming cells from patients carrying disease-associated mutations, and subsequent differentiation into the cell type of interest, researchers now have the opportunity to study disease-specific cell types which wer...

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Publication status:
Published

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Publisher copy:
10.1042/bst20120159

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
Journal:
Biochemical Society transactions
Volume:
40
Issue:
5
Pages:
1152-1157
Publication date:
2012-10-05
DOI:
EISSN:
1470-8752
ISSN:
0300-5127
URN:
uuid:80fe2d1e-f11d-4a39-a14c-58bc6e2dc2dc
Source identifiers:
352475
Local pid:
pubs:352475

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