Journal article icon

Journal article

Neuregulin1-induced cell migration is impaired in schizophrenia: association with neuregulin1 and catechol-o-methyltransferase gene polymorphisms.

Abstract:

Neuregulin1 (NRG1), a candidate susceptibility gene for schizophrenia, plays a critical role in neuronal migration and central nervous system development. However, its relation to schizophrenia pathogenesis is unknown. Here we show that B lymphoblasts migrate to NRG1 through the ErbB-signaling system as observed in neuronal cells. We assessed NRG1-induced cell migration in B lymphoblasts from patients with schizophrenia and found that NRG1-induced migration is significantly decreased compared...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1038/sj.mp.4001994

Authors


Ren-Patterson, R More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Expand authors...
Journal:
Molecular psychiatry
Volume:
12
Issue:
10
Pages:
946-957
Publication date:
2007-10-05
DOI:
EISSN:
1476-5578
ISSN:
1359-4184
URN:
uuid:80d73b0c-090a-4b62-94c5-c773f6cfce3a
Source identifiers:
139447
Local pid:
pubs:139447

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP