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Thesis

The regulation of Mps1 kinase during mitosis

Abstract:

The spindle assembly checkpoint (SAC), a conserved surveillance system, ensures genomic stability by delaying anaphase entry until all sister chromatids are attached to the mitotic spindle. The SAC network is active at unattached kinetochores and a complex signalling cascade culminates in the production of a diffusible ‘wait anaphase’ signal. Regulation of protein:protein interactions by reversible phosphorylation is critical in this signalling pathway. The checkpoint kinase Mps1, a centra...

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Division:
MSD
Department:
Pathology Dunn School
Department:
University of Oxford
Role:
Author

Contributors

Department:
University of Oxford
Role:
Supervisor
EPA studentship More from this funder
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:80ced82c-6424-45a4-bdda-f83c270d3eeb
Deposit date:
2018-06-14

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