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Journal article

Complete human CD1a deficiency on Langerhans cells due to a rare point mutation in the coding sequence.

Abstract:

The family of CD1 molecules is structurally similar to MHC class I molecules, but the 2 protein families mediate fundamentally different immune functions. MHC class I molecules present peptides to T cells, whereas CD1 molecules present lipids to natural killer T cells and other CD1-restricted T cells.1 CD1a is highly expressed on human Langerhans cells (LCs), a specialized mononuclear phagocyte that is prevalent in the epithelial cell layer of the skin and mucosal surfaces. Epidermal LCs can ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.jaci.2016.05.028

Authors


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Singapore Agency for Science, Technology and Research More from this funder
Wellcome Trust More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Journal of Allergy and Clinical Immunology Journal website
Volume:
138
Issue:
6
Pages:
1709-1712.e11
Publication date:
2016-06-05
Acceptance date:
2016-05-17
DOI:
ISSN:
1097-6825 and 0091-6749
Pubs id:
pubs:627927
URN:
uri:80c3551b-4d71-4327-b251-d75a33bb4eff
UUID:
uuid:80c3551b-4d71-4327-b251-d75a33bb4eff
Local pid:
pubs:627927
Language:
English
Keywords:

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