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Exhaustion of cytotoxic T cells during adoptive immunotherapy of virus carrier mice can be prevented by B cells or CD4+ T cells.

Abstract:

Rapid disappearance of antiviral CTL after transfusion into persistently infected individuals is a serious limitation of adoptive immunotherapy protocols. In the mouse model of persistent infection with lymphocytic choriomeningitis virus (LCMV) naive or immune virus-specific donor CD8+ T cells are exhausted after transfusion into carrier recipients with similar kinetics. Here we show that cotransfusion of immune CD4+ T cells prevents exhaustion of immune CD8+ T cells. Interestingly, cotransfe...

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Publication status:
Published

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Authors


Hunziker, L More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division, Biomedical Research Centre
Zinkernagel, RM More by this author
Journal:
European journal of immunology
Volume:
32
Issue:
2
Pages:
374-382
Publication date:
2002-02-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:80b2eff4-574d-45b4-b905-4f863740667b
Source identifiers:
13753
Local pid:
pubs:13753

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