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Interplay between lysine methylation and Cdk phosphorylation in growth control by the retinoblastoma protein.

Abstract:

As a critical target for cyclin-dependent kinases (Cdks), the retinoblastoma tumour suppressor protein (pRb) controls early cell cycle progression. We report here a new type of regulation that influences Cdk recognition and phosphorylation of substrate proteins, mediated through the targeted methylation of a critical lysine residue in the Cdk substrate recognition site. In pRb, lysine (K) 810 represents the essential and conserved basic residue (SPXK) required for cyclin/Cdk recognition and p...

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Publication status:
Published

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Publisher copy:
10.1038/emboj.2010.311

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP
Oppermann, U More by this author
La Thangue, NB More by this author
Journal:
The EMBO journal
Volume:
30
Issue:
2
Pages:
317-327
Publication date:
2011-01-05
DOI:
EISSN:
1460-2075
ISSN:
0261-4189
URN:
uuid:809dfc80-2e72-45f3-81b1-77be9ff636ce
Source identifiers:
322023
Local pid:
pubs:322023

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