Journal article icon

Journal article

Location and time-dependent control of rejection by regulatory T cells culminates in a failure to generate memory T cells.

Abstract:

Adaptive CD25(+)CD4(+) regulatory T cells (Treg) can be induced following exposure to alloantigen and may function alongside naturally occurring Treg to suppress allograft rejection when present in sufficient numbers. However, the location of the Treg as they function in vivo and the mechanisms used to control donor-reactive T cells remains ill-defined. In this study, we used a CD8(+) TCR transgenic model of skin allograft rejection to characterize in vivo activity of donor-reactive Treg cell...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


Expand authors...
Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
180
Issue:
10
Pages:
6640-6648
Publication date:
2008-05-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:809d7f87-c55d-4d0d-89fa-35d9866db4bd
Source identifiers:
135978
Local pid:
pubs:135978

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP