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Journal article

Differential sensitivity of mouse strains to an N-alkylated imino sugar: glycosphingolipid metabolism and acrosome formation.

Abstract:

This review deals with the pharmacological properties of an alkylated monosaccharide mimetic, N-butyldeoxynojirimycin (NB-DNJ). This compound is of pharmacogenetic interest because one of its biological effects in mice - impairment of spermatogenesis, leading to male infertility - depends greatly on the genetic background of the animal. In susceptible mice, administration of NB-DNJ perturbs the formation of an organelle, the acrosome, in early post-meiotic male germ cells. In all recipient mi...

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Publication status:
Published

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Publisher copy:
10.2217/14622416.9.6.717

Authors


van der Spoel, AC More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Journal:
Pharmacogenomics
Volume:
9
Issue:
6
Pages:
717-731
Publication date:
2008-06-05
DOI:
EISSN:
1744-8042
ISSN:
1462-2416
URN:
uuid:809b8f72-c071-4f11-a051-16d49d933b41
Source identifiers:
54083
Local pid:
pubs:54083

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