Exploring the pattern and neural correlates of neuropsychological impairment in late-life depression.

Journal article

BACKGROUND: Neuropsychological impairment is a key feature of late-life depression, with deficits observed across multiple domains. However, it is unclear whether deficits in multiple domains represent relatively independent processes with specific neural correlates or whether they can be explained by cognitive deficits in executive function or processing speed. METHOD: We examined group differences across five domains (episodic memory; executive function; language skills; processing speed; v...

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Authors: Sexton, C; McDermott, L; Kalu, U; Herrmann, L; Bradley, K

• Publication status: Published
• Journal: Psychological medicine
• Volume: 42
• Issue: 6
• Pages: 1195-1202
• Publication date: 2012-06-01
• DOI: 10.1017/s0033291711002352
• EISSN: 1469-8978
• ISSN: 0033-2917
• Language: English
• Keywords: Anisotropy; Case-Control Studies; Humans; Brain Mapping; Severity of Illness Index; Middle Aged; Aged; Cognition Disorders; Female; Male; Magnetic Resonance Imaging; Neuropsychological Tests; Depressive Disorder; Age Factors; Memory, Episodic; Neuropsychology; Executive Function; Brain; Reaction Time