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Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease.

Abstract:

BACKGROUND: Estimates of the heritability of plasma fibrinogen concentration, an established predictor of cardiovascular disease, range from 34% to 50%. Genetic variants so far identified by genome-wide association studies explain only a small proportion (<2%) of its variation. METHODS AND RESULTS: We conducted a meta-analysis of 28 genome-wide association studies including >90 000 subjects of European ancestry, the first genome-wide association meta-analysis of fibrinogen levels in 7 s...

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Publication status:
Published

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Journal:
Circulation
Volume:
128
Issue:
12
Pages:
1310-1324
Publication date:
2013-09-05
DOI:
EISSN:
1524-4539
ISSN:
0009-7322
URN:
uuid:808a9ea4-1edc-4e4c-82b2-15e6f40e3483
Source identifiers:
420887
Local pid:
pubs:420887

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