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MiR-142-3p controls the specification of definitive hemangioblasts during ontogeny

Abstract:

Hematopoietic stem cells (HSCs) emerge during embryogenesis from hemogenic endothelium, but it remains unclear how the HSC lineage is initially established from mesoderm during ontogeny. In Xenopus, the definitive hemangioblast precursors of the HSC lineage have been identified in dorsal lateral plate (DLP) mesoderm, and a transcriptional gene regulatory network (GRN) controlling hemangioblast programming has been elucidated. Herein, we identify an essential role for microRNAs (miRNAs) in est...

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Journal:
Developmental Cell
Volume:
26
Issue:
3
Pages:
237-249
Publication date:
2013-08-12
DOI:
EISSN:
1878-1551
ISSN:
1534-5807
URN:
uuid:8081c825-1b93-4280-9319-9a7cdc6b4fb4
Source identifiers:
419340
Local pid:
pubs:419340
Language:
English

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