- Abstract:
-
Hematopoietic stem cells (HSCs) emerge during embryogenesis from hemogenic endothelium, but it remains unclear how the HSC lineage is initially established from mesoderm during ontogeny. In Xenopus, the definitive hemangioblast precursors of the HSC lineage have been identified in dorsal lateral plate (DLP) mesoderm, and a transcriptional gene regulatory network (GRN) controlling hemangioblast programming has been elucidated. Herein, we identify an essential role for microRNAs (miRNAs) in est...
Expand abstract - Publisher copy:
- 10.1016/j.devcel.2013.06.023
-
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- Journal:
- Developmental Cell
- Volume:
- 26
- Issue:
- 3
- Pages:
- 237-249
- Publication date:
- 2013-08-12
- DOI:
- EISSN:
-
1878-1551
- ISSN:
-
1534-5807
- URN:
-
uuid:8081c825-1b93-4280-9319-9a7cdc6b4fb4
- Source identifiers:
-
419340
- Local pid:
- pubs:419340
- Language:
- English
- Copyright date:
- 2013
Journal article
MiR-142-3p controls the specification of definitive hemangioblasts during ontogeny
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