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Multiscale modelling of vascular tumour growth in 3D: the roles of domain size & boundary condition

Abstract:

We investigate a three-dimensional multiscale model of vascular tumour growth, which couples blood flow, angiogenesis, vascular remodelling, nutrient/growth factor transport, movement of, and interactions between, normal and tumour cells, and nutrient-dependent cell cycle dynamics within each cell. In particular, we determine how the domain size, aspect ratio and initial vascular network influence the tumour's growth dynamics and its long-time composition. We establish whether it is possible ...

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H. M. Byrne More by this author
V Estrella More by this author
T. Alarcon More by this author
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Publication date:
2011
URN:
uuid:807f22ad-5f84-4812-89f3-bfe22fb08b0e
Local pid:
oai:eprints.maths.ox.ac.uk:1057

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