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Can overall results of clinical trials be applied to all patients?

Abstract:

It is generally assumed that the overall results of a clinical trial are generalisable to all patients in the trial and all similar future patients; in other words, that the relative treatment effect in individual patients is similar to the overall trial result. Although this assumption underpins the application of trial results to clinical practice, it has rarely been tested. By independently derived prognostic models, the results of the European Carotid Surgery Trial and the UK-TIA Aspirin ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience, Biomedical Research Centre
Role:
Author
Journal:
Lancet
Volume:
345
Issue:
8965
Pages:
1616-1619
Publication date:
1995-06-05
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
URN:
uuid:806f219c-2093-4801-8ccf-21ac693b2980
Source identifiers:
244491
Local pid:
pubs:244491

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