- Abstract:
-
The Kaposi's sarcoma-associated human herpesvirus 8 (KSHV/HHV8) encodes a protein similar to cellular cyclins. This cyclin is most closely related to cellular D-type cyclins, but biochemically it behaves atypically in various respects. Complexes formed between the viral cyclin and the cyclin-dependent kinase subunit, cdk6, can phosphorylate a wider range of substrates and are resistant to cdk inhibitory proteins. We show here that the KSHV-cyclin-cdk6 complex phosphorylates p27(Kip) on a C-te...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1093/emboj/18.3.644
-
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- Journal:
- The EMBO journal
- Volume:
- 18
- Issue:
- 3
- Pages:
- 644-653
- Publication date:
- 1999-02-05
- DOI:
- EISSN:
-
1460-2075
- ISSN:
-
0261-4189
- URN:
-
uuid:806879a8-9576-47c8-8ccc-a4104a40c70e
- Source identifiers:
-
84030
- Local pid:
- pubs:84030
- Language:
- English
- Keywords:
- Copyright date:
- 1999
Journal article
Degradation of p27(Kip) cdk inhibitor triggered by Kaposi's sarcoma virus cyclin-cdk6 complex.
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