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Degradation of p27(Kip) cdk inhibitor triggered by Kaposi's sarcoma virus cyclin-cdk6 complex.

Abstract:

The Kaposi's sarcoma-associated human herpesvirus 8 (KSHV/HHV8) encodes a protein similar to cellular cyclins. This cyclin is most closely related to cellular D-type cyclins, but biochemically it behaves atypically in various respects. Complexes formed between the viral cyclin and the cyclin-dependent kinase subunit, cdk6, can phosphorylate a wider range of substrates and are resistant to cdk inhibitory proteins. We show here that the KSHV-cyclin-cdk6 complex phosphorylates p27(Kip) on a C-te...

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Publication status:
Published

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Publisher copy:
10.1093/emboj/18.3.644

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Journal:
The EMBO journal
Volume:
18
Issue:
3
Pages:
644-653
Publication date:
1999-02-05
DOI:
EISSN:
1460-2075
ISSN:
0261-4189
URN:
uuid:806879a8-9576-47c8-8ccc-a4104a40c70e
Source identifiers:
84030
Local pid:
pubs:84030

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