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Cone photoreceptor neuroprotection conferred by CNTF in a novel in vivo model of battlefield retinal laser injury.

Abstract:

PURPOSE: To develop a reproducible laboratory model to simulate a battlefield foveal laser injury and to test potential neuroprotective effects of a single injection treatment that might be administered in a military setting. METHODS: Frequency-doubled 532-nm Nd:YAG laser was used to induce a threshold retinal injury bilaterally in transgenic reporter mice that have fluorescent cones. Intravitreal injection of ciliary neurotrophic factor (CNTF) was then administered to the lasered eye and co...

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Publication status:
Published

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Publisher copy:
10.1167/iovs.13-11623

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Role:
Author
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Journal:
Investigative ophthalmology and visual science
Volume:
54
Issue:
8
Pages:
5456-5465
Publication date:
2013-08-05
DOI:
EISSN:
1552-5783
ISSN:
0146-0404
URN:
uuid:8061c44d-c647-4b9c-bb43-796fe64bb62d
Source identifiers:
401915
Local pid:
pubs:401915

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