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Journal article

Endothelial cell-specific reactive oxygen species production increases susceptibility to aortic dissection.

Abstract:

BACKGROUND: Increased production of reactive oxygen species (ROS) throughout the vascular wall is a feature of cardiovascular disease states, but therapeutic strategies remain limited by our incomplete understanding of the role and contribution of specific vascular cell ROS to disease pathogenesis. To investigate the specific role of endothelial cell (EC) ROS in the development of structural vascular disease, we generated a mouse model of endothelium-specific Nox2 overexpression and tested th...

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Publication status:
Published

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Authors


Douglas, G More by this author
Bendall, JK More by this author
McNeill, E More by this author
Crabtree, MJ More by this author
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Journal:
Circulation
Volume:
129
Issue:
25
Pages:
2661-2672
Publication date:
2014-06-05
DOI:
EISSN:
1524-4539
ISSN:
0009-7322
URN:
uuid:805d5eb4-e1aa-4f89-91d0-3dc08422bd22
Source identifiers:
465011
Local pid:
pubs:465011

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