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Meisetz and the birth of the KRAB motif.

Abstract:

The largest family of transcription factors in mammals is of Cys(2)His(2) zinc finger-proteins, each with an NH(2)-terminal KRAB motif. Extensive expansions of this family have occurred in separate mammalian lineages, with approximately 400 such genes known in the human genome. Despite their widespread occurrence, the evolutionary provenance of the KRAB motif is unclear since previously it has not been found outside of the tetrapod vertebrates. Here, we show that homologues of the histone met...

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Publisher copy:
10.1093/bioinformatics/btl498

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Journal:
Bioinformatics (Oxford, England)
Volume:
22
Issue:
23
Pages:
2841-2845
Publication date:
2006-12-01
DOI:
EISSN:
1367-4811
ISSN:
1367-4803
Source identifiers:
238597

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