Meisetz and the birth of the KRAB motif.

Journal article

The largest family of transcription factors in mammals is of Cys(2)His(2) zinc finger-proteins, each with an NH(2)-terminal KRAB motif. Extensive expansions of this family have occurred in separate mammalian lineages, with approximately 400 such genes known in the human genome. Despite their widespread occurrence, the evolutionary provenance of the KRAB motif is unclear since previously it has not been found outside of the tetrapod vertebrates. Here, we show that homologues of the histone met...

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Authors: Birtle, Z; Ponting, C

• Journal: Bioinformatics (Oxford, England)
• Volume: 22
• Issue: 23
• Pages: 2841-2845
• Publication date: 2006-12-01
• DOI: 10.1093/bioinformatics/btl498
• EISSN: 1367-4811
• ISSN: 1367-4803
• Language: English
• Keywords: Histone-Lysine N-Methyltransferase; Carrier Proteins; Transcription Factors; Molecular Sequence Data; Mice; Animals; Amino Acid Motifs; Sequence Homology, Nucleic Acid; Repressor Proteins; Evolution, Molecular; Base Sequence; Protein Methyltransferases; Sea Urchins; Nuclear Proteins; Chromosome Mapping; Sequence Analysis, DNA