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Reduced amounts and abnormal forms of phospholipase C zeta (PLCzeta) in spermatozoa from infertile men.

Abstract:

BACKGROUND: In mammals, oocyte activation at fertilization is thought to be induced by the sperm-specific phospholipase C zeta (PLCzeta). However, it still remains to be conclusively shown that PLCzeta is the endogenous agent of oocyte activation. Some types of human infertility appear to be caused by failure of the sperm to activate and this may be due to specific defects in PLCzeta. METHODS AND RESULTS: Immunofluorescence studies showed PLCzeta to be localized in the equatorial region of sp...

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Publication status:
Published

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Publisher copy:
10.1093/humrep/dep207

Authors


Heytens, E More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
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Institution:
University of Oxford
Department:
Oxford, MSD, Obstetrics and Gynaecology
Lambrecht, S More by this author
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Journal:
Human reproduction (Oxford, England)
Volume:
24
Issue:
10
Pages:
2417-2428
Publication date:
2009-10-05
DOI:
EISSN:
1460-2350
ISSN:
0268-1161
URN:
uuid:8045d9d8-830a-4ef4-90df-2a19100a3ccb
Source identifiers:
97516
Local pid:
pubs:97516

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