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Hippocampal mGluR1-dependent long-term potentiation requires NAADP-mediated acidic store Ca2+ signaling

Abstract:

Acidic organelles, such as endosomes and lysosomes, store Ca2+ that is released in response to intracellular increases in the second messenger nicotinic acid adenine dinucleotide phosphate (NAADP). In neurons, NAADP and Ca2+ signaling contribute to synaptic plasticity, a process of activity-dependent long-term potentiation (LTP) [or, alternatively, long-term depression (LTD)] of synaptic strength and neuronal transmission that is critical for neuronal function and memory formation. We explore...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1126/scisignal.aat9093

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pharmacology
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pharmacology
Padamsey, Z More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pharmacology
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pharmacology
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Funding agency for:
Galione, A
Publisher:
American Association for the Advancement of Science Publisher's website
Journal:
Science Signaling Journal website
Volume:
11
Issue:
558
Pages:
eaat9093
Publication date:
2018-11-29
Acceptance date:
2018-11-06
DOI:
EISSN:
1937-9145
ISSN:
1945-0877
Pubs id:
pubs:944446
URN:
uri:80414ec5-2f77-45f0-9183-238823aaff60
UUID:
uuid:80414ec5-2f77-45f0-9183-238823aaff60
Local pid:
pubs:944446

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