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The Plasmodium berghei sexual stage antigen PSOP12 induces anti-malarial transmission blocking immunity both in vivo and in vitro.

Abstract:

Anti-malarial transmission-blocking vaccines (TBVs) aim to inhibit the transmission of Plasmodium from humans to mosquitoes by targeting the sexual/ookinete stages of the parasite. Successful use of such interventions will subsequently result in reduced cases of malarial infection within a human population, leading to local elimination. There are currently only five lead TBV candidates under examination. There is a consequent need to identify novel antigens to allow the formulation of new pot...

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Journal:
Vaccine
Volume:
33
Issue:
3
Pages:
437-445
Publication date:
2015-01-05
DOI:
EISSN:
1873-2518
ISSN:
0264-410X
URN:
uuid:803d7c06-d927-47ca-a633-3e4c15312a4b
Source identifiers:
493354
Local pid:
pubs:493354

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