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Journal article

Epigenetic targeting of bromodomain protein BRD4 counteracts cancer cachexia and prolongs survival

Abstract:

Cancer cachexia is a devastating metabolic syndrome characterized by systemic inflammation and massive muscle and adipose tissue wasting. Although it is responsible for approximately one-third of cancer deaths, no effective therapies are available and the underlying mechanisms have not been fully elucidated. We previously identified the bromodomain and extra-terminal domain (BET) protein BRD4 as an epigenetic regulator of muscle mass. Here we show that the pan-BET inhibitor (+)-JQ1 protects t...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/s41467-017-01645-7

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ORCID:
0000-0003-0465-9470
Fittipaldi, R More by this author
Sartori, R More by this author
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Telethon GGP13165 More from this funder
French Association for Myophaties More from this funder
Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
8
Pages:
1707
Publication date:
2017-11-22
Acceptance date:
2017-10-05
DOI:
EISSN:
2041-1723
ISSN:
2041-1723
Pubs id:
pubs:807016
URN:
uri:803a18b7-078f-433f-8bbf-cbd97d10566d
UUID:
uuid:803a18b7-078f-433f-8bbf-cbd97d10566d
Local pid:
pubs:807016
Language:
English
Keywords:

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