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A complex phosphodiesterase system controls β-adrenoceptor signalling in cardiomyocytes

Abstract:

β-Adrenergic signalling mediates the positive inotropic effect of catecholamines on cardiomyocytes, mainly through cAMP generation and subsequent activation of PKA (protein kinase A). Given the large diversity of PKA targets within cardiac cells, a precisely regulated and confined activity of such signalling pathways is essential for the specificity of response. PDEs (phosphodiesterases) constitute the only cAMP-degrading mechanism and are expressed in the cardiomyocyte in at least 5 family v...

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Publisher copy:
10.1042/BST0340510

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics, BHF Centre of Research Excellence
Role:
Author
Journal:
Biochemical Society Transactions
Volume:
34
Issue:
4
Pages:
510-511
Publication date:
2006-08-05
DOI:
ISSN:
0300-5127
URN:
uuid:80318c7c-4a26-4477-bfed-99d727bcc608
Source identifiers:
238574
Local pid:
pubs:238574

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