- Abstract:
-
β-Adrenergic signalling mediates the positive inotropic effect of catecholamines on cardiomyocytes, mainly through cAMP generation and subsequent activation of PKA (protein kinase A). Given the large diversity of PKA targets within cardiac cells, a precisely regulated and confined activity of such signalling pathways is essential for the specificity of response. PDEs (phosphodiesterases) constitute the only cAMP-degrading mechanism and are expressed in the cardiomyocyte in at least 5 family v...
Expand abstract - Publisher copy:
- 10.1042/BST0340510
-
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- Journal:
- Biochemical Society Transactions
- Volume:
- 34
- Issue:
- 4
- Pages:
- 510-511
- Publication date:
- 2006-08-05
- DOI:
- ISSN:
-
0300-5127
- URN:
-
uuid:80318c7c-4a26-4477-bfed-99d727bcc608
- Source identifiers:
-
238574
- Local pid:
- pubs:238574
- Language:
- English
- Keywords:
- Copyright date:
- 2006
Journal article
A complex phosphodiesterase system controls β-adrenoceptor signalling in cardiomyocytes
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