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A complex phosphodiesterase system controls β-adrenoceptor signalling in cardiomyocytes

Abstract:

β-Adrenergic signalling mediates the positive inotropic effect of catecholamines on cardiomyocytes, mainly through cAMP generation and subsequent activation of PKA (protein kinase A). Given the large diversity of PKA targets within cardiac cells, a precisely regulated and confined activity of such signalling pathways is essential for the specificity of response. PDEs (phosphodiesterases) constitute the only cAMP-degrading mechanism and are expressed in the cardiomyocyte in at least 5 family v...

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Publisher copy:
10.1042/BST0340510

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
Biochemical Society Transactions
Volume:
34
Issue:
4
Pages:
510-511
Publication date:
2006-08-01
DOI:
ISSN:
0300-5127
Source identifiers:
238574
Language:
English
Keywords:
Pubs id:
pubs:238574
UUID:
uuid:80318c7c-4a26-4477-bfed-99d727bcc608
Local pid:
pubs:238574
Deposit date:
2013-11-16

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