Journal article
Inhibition of shedding of low-density lipoprotein receptor-related protein 1 reverses cartilage matrix degradation in osteoarthritis
- Abstract:
-
Objective The aggrecanase ADAMTS-5 and the collagenase matrix metalloproteinase 13 (MMP-13) are constitutively secreted by chondrocytes in normal cartilage, but rapidly endocytosed via the cell surface endocytic receptor low-density lipoprotein receptor–related protein 1 (LRP-1) and subsequently degraded. This endocytic system is impaired in osteoarthritic (OA) cartilage due to increased ectodomain shedding of LRP-1. The aim of this study was to identify the LRP-1 sheddase(s... Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
+ Arthritis Research UK
More from this funder
Funding agency for:
Yamamoto, K
Troeberg, L
Grant:
20563
19466
+ National Institute of Arthritis and Musculoskeletal and Skin Diseases
More from this funder
Funding agency for:
Nagase, H
Grant:
AR40994
Bibliographic Details
- Publisher:
- Wiley
- Journal:
- Arthritis and Rheumatology More from this journal
- Volume:
- 69
- Issue:
- 6
- Pages:
- 1246–1256
- Publication date:
- 2017-02-01
- Acceptance date:
- 2017-02-21
- DOI:
- ISSN:
-
2326-5205
Item Description
- Language:
-
English
- Keywords:
- Pubs id:
-
pubs:682023
- UUID:
-
uuid:802c484e-941a-4ccd-9047-e05c4f24c4e4
- Local pid:
-
pubs:682023
- Deposit date:
-
2017-03-01
Terms of use
- Copyright holder:
- Yamamoto et al
- Copyright date:
- 2017
- Notes:
-
Copyright © 2017 The Authors. Arthritis & Rheumatology published by Wiley Periodicals, Inc. on behalf of American College of Rheumatology.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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