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Journal article

Effects of the alpha-mannosidase inhibitors, 1,4-dideoxy-1,4-imino-D-mannitol and swainsonine, on glycoprotein catabolism in cultured macrophages.

Abstract:

Thioglycollate-stimulated murine peritoneal macrophages were cultured for eight days in the presence of swainsonine, or 1,4-dideoxy-1,4-imino-D-mannitol (DIM), or both of these competitive alpha-mannosidase inhibitors together. Analysis of accumulated high-mannose oligosaccharides by reversed phase HPLC after perbenzoylation revealed that DIM- and DIM-plus swainsonine-treated macrophages contained larger amounts of Man7GlcNAc, Man8GlcNAc and Man9GlcNAc, while swainsonine-treated macrophages c...

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Publication status:
Published

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Publisher copy:
10.1007/bf01050651

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Journal:
Glycoconjugate journal
Volume:
6
Issue:
2
Pages:
229-240
Publication date:
1989-01-01
DOI:
EISSN:
1573-4986
ISSN:
0282-0080
URN:
uuid:80241565-7e8d-4c92-b73b-7a98f04efa9c
Source identifiers:
43071
Local pid:
pubs:43071

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