- Abstract:
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Properdin is a serum glycoprotein that upregulates the alternative pathway of complement by stabilizing the C3bBb complex. It also binds sulphated glycoconjugates, such as sulphatide, in vitro. Properdin is composed of cyclic dimers, trimers and tetramers of a 53 kDa monomeric subunit. The monomer contains an N-terminal region of no known homology and six thrombospondin type 1 repeats (TSRs) of approximately sixty amino acids. The sixth TSR of properdin contains an insertion of a...
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- Publication date:
- 1994
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- URN:
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uuid:80236e86-789e-4028-aad0-e72223f7645a
- Local pid:
- td:603835457
- Language:
- English
- Subjects:
- Copyright holder:
- Higgins, Jonathan M.G.
- Copyright date:
- 1994
- Notes:
- The digital copy of this thesis has been made available thanks to the generosity of Dr Leonard Polonsky
Thesis
Protein engineering of human properdin
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