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Protein engineering of human properdin

Abstract:

Properdin is a serum glycoprotein that upregulates the alternative pathway of complement by stabilizing the C3bBb complex. It also binds sulphated glycoconjugates, such as sulphatide, in vitro. Properdin is composed of cyclic dimers, trimers and tetramers of a 53 kDa monomeric subunit. The monomer contains an N-terminal region of no known homology and six thrombospondin type 1 repeats (TSRs) of approximately sixty amino acids. The sixth TSR of properdin contains an insertion of a...

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Institution:
University of Oxford
Department:
Faculty of Biological Sciences Division
Role:
Author

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Role:
Supervisor
Role:
Supervisor
Publication date:
1994
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Barcode:
603835457
URN:
uuid:80236e86-789e-4028-aad0-e72223f7645a
Local pid:
td:603835457
Language:
English
Subjects:

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