The pharmacokinetics of atovaquone and proguanil in pregnant women with acute falciparum malaria.

Journal article

OBJECTIVE: To determine the pharmacokinetic properties of atovaquone, proguanil, and the triazine metabolite cycloguanil in women with recrudescent multi-drug resistant falciparum malaria during the second and third trimesters of pregnancy treated by artesunate-atovaquone-proguanil. METHODS: Serial plasma concentrations of atovaquone, proguanil and cycloguanil were measured in 24 women at baseline and after the final dose of the 3-day treatment with atovaquone (20 mg/kg/day) plus proguanil (...

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Authors: Mcgready, R; Stepniewska, K; Edstein, MD; Cho, T; Gilveray, G

• Publication status: Published
• Journal: European journal of clinical pharmacology
• Volume: 59
• Issue: 7
• Pages: 545-552
• Publication date: 2003-10-01
• DOI: 10.1007/s00228-003-0652-9
• EISSN: 1432-1041
• ISSN: 0031-6970
• Language: English
• Keywords: Proguanil; Naphthoquinones; Pregnancy Outcome; Drug Resistance, Multiple; Drug Therapy, Combination; Female; Drug Combinations; Sesquiterpenes; Thailand; Pregnancy; Atovaquone; Pregnancy Trimester, Second; Acute Disease; Antimalarials; Pregnancy Complications, Parasitic; Humans; Artemisinins; Malaria, Falciparum; Pregnancy Trimester, Third