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The pharmacokinetics of atovaquone and proguanil in pregnant women with acute falciparum malaria.

Abstract:

OBJECTIVE: To determine the pharmacokinetic properties of atovaquone, proguanil, and the triazine metabolite cycloguanil in women with recrudescent multi-drug resistant falciparum malaria during the second and third trimesters of pregnancy treated by artesunate-atovaquone-proguanil. METHODS: Serial plasma concentrations of atovaquone, proguanil and cycloguanil were measured in 24 women at baseline and after the final dose of the 3-day treatment with atovaquone (20 mg/kg/day) plus proguanil (...

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Publication status:
Published

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Publisher copy:
10.1007/s00228-003-0652-9

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Stepniewska, K More by this author
Edstein, MD More by this author
Gilveray, G More by this author
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Journal:
European journal of clinical pharmacology
Volume:
59
Issue:
7
Pages:
545-552
Publication date:
2003-10-05
DOI:
EISSN:
1432-1041
ISSN:
0031-6970
URN:
uuid:8012cc89-d065-4979-8c1e-5c09c5997c87
Source identifiers:
14864
Local pid:
pubs:14864

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