Journal article
Exchange of functional domains between a bacterial conjugative relaxase and the integrase of the human adeno-associated virus
- Abstract:
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Endonucleases of the HUH family are specialized in processing single-stranded DNA in a variety of evolutionarily highly conserved biological processes related to mobile genetic elements. They share a structurally defined catalytic domain for site-specific nicking and strand-transfer reactions, which is often linked to the activities of additional functional domains, contributing to their overall versatility. To assess if these HUH domains could be interchanged, we created a chimeric protein f...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 7.0MB)
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- Publisher copy:
- 10.1371/journal.pone.0200841
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Authors
Funding
+ Spanish Ministry of Economy and Competitiveness
More from this funder
Grant:
BIO2013-46414-P to ML
Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS ONE Journal website
- Volume:
- 13
- Issue:
- 7
- Article number:
- e0200841
- Publication date:
- 2018-07-17
- Acceptance date:
- 2018-07-02
- DOI:
- ISSN:
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1932-6203
- Pmid:
-
30016371
- Source identifiers:
-
891219
Item Description
- Language:
- English
- Pubs id:
-
pubs:891219
- UUID:
-
uuid:800e5e71-81e4-4a34-ad2a-2fb508c870db
- Local pid:
- pubs:891219
- Deposit date:
- 2018-08-30
Terms of use
- Copyright holder:
- Agúndez et al
- Copyright date:
- 2018
- Notes:
- Copyright © 2018 Agúndez et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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