- Abstract:
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Some neuropsychiatric disease, including schizophrenia, may originate during prenatal development, following periods of gestational hypoxia and placental oxidative stress. Here we investigated if gestational hypoxia promotes damaging secretions from the placenta that affect fetal development and whether a mitochondria-targeted antioxidant MitoQ might prevent this. Gestational hypoxia caused low birth-weight and changes in young adult offspring brain, mimicking those in human neuropsychiatric ...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Publisher's version
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(pdf, 4.5MB)
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- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Scientific Reports Journal website
- Volume:
- 7
- Issue:
- 9079
- Pages:
- 1-16
- Publication date:
- 2017-08-22
- Acceptance date:
- 2017-06-09
- ISSN:
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10.1038/s41598-017-06300-1 and 2045-2322
- Pubs id:
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pubs:700134
- URN:
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uri:800d116f-a31d-44fb-a98e-defc60d7d537
- UUID:
-
uuid:800d116f-a31d-44fb-a98e-defc60d7d537
- Local pid:
- pubs:700134
- Copyright holder:
- © Phillips et al, 2017
- Copyright date:
- 2017
- Notes:
- This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Journal article
Treatment of the placenta prevents adverse effects of gestational hypoxia on fetal brain development
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Funding
Pervoli Trust
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Canadian Institutes of Health Research
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Women and Children’s Health Research Institute
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Stollery Children’s Hospital Foundation
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Royal Alexandra Hospital Foundation
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