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Alternative vaccine administration by powder injection: Needle-free dermal delivery of the glycoconjugate meningococcal group Y vaccine

Abstract:

Powder-injectors use gas propulsion to deposit lyophilised drug or vaccine particles in the epidermal and sub epidermal layers of the skin. We prepared dry-powder (Tg = 45.2 ± 0.5°C) microparticles (58.1 μm) of a MenY-CRM197 glyconjugate vaccine (0.5% wt.) for intradermal needle-free powder injection (NFPI). SFD used ultrasound atomisation of the liquid vaccine-containing excipient feed, followed by lyophilisation above the glass transition temperature (Tg' = - 29.9 ± 0.3°C). This resulted in...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0183427

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Department:
Oxford, Oxford Martin School
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Department:
Oxford, MPLS, Engineering Science
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Department:
Oxford, MPLS, Engineering Science
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Department:
Oxford, MSD, Paediatrics
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS ONE Journal website
Volume:
12
Issue:
8
Pages:
Article: e0183427
Publication date:
2017-08-24
DOI:
ISSN:
1932-6203
Pubs id:
pubs:724642
URN:
uri:800c8186-3dbb-4997-a11e-8faffd607f4a
UUID:
uuid:800c8186-3dbb-4997-a11e-8faffd607f4a
Local pid:
pubs:724642
Language:
English

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